منابع مشابه
Stimulation by octanoate of insulin release from isolated rat pancreas.
Using pieces of rat pancreas incubated bation medium to 3.0 mg./ml. without in Krebs-bicarbonate buffer containing addition of octanoate produced a slight0.6 mg. glucose/ml., it has been found ly smaller though significant (p < .05) that addition of 3.0 mM. octanoate to increase in insulin release (2.96 t 0.96 the incubation medium significantly (p &J./mg.) above control levels. In con< .OOl) i...
متن کاملStimulation by prostaglandin E2 of glucagon and insulin release from isolated rat pancreas.
To ascertain whether prostaglandins (PG) may play a role in the secretion of glucagon and in an attempt to elucidate the conflicting observations on the effects of PG on insulin release, the isolated intact rat pancreas was perfused with solutions containing 1.1 x 10(-9) to 1.8 x 10(-5)m PGE2. In the presence of 5.6 mM glucose significant increments in portal venous effluent levels of glucagon ...
متن کاملEffect of from the Sustained Hyperg Isolated Perfused lycemia on the Rat Pancreas Release of Insulin
The modulation of insulin release from the isolated pancreas using normal rats rendered hyperglycemic by in vivo glucose infusion was studied. In 24 h and 48 h hyperglycemic rats , the increase i n the amount of insulin released was reduced in response to glucose challenge , but was unchanged in relation to arginine challenge. In 48 h hyperglycemic rats insulin secretion after glucagon challeng...
متن کاملEffect of muscimol on glucose-stimulated somatostatin and insulin release from the isolated, perfused rat pancreas.
This study examines the effect of muscimol, a high affinity, specific gamma-aminobutyric acid (GABA) agonist, on glucose-stimulated somatostatin and insulin release from the isolated, perfused rat pancreas. Perfusion with low glucose (50 mg/dl) conditions resulted in basal somatostatin release of 46 +/- 4 pg/ml. Basal insulin release was less than 20 microU/ml. High glucose (300 mg/dl) conditio...
متن کاملKinetics of insulin release from the perfused rat pancreas caused by glucose, glucosamine, and galactose.
Under appropriate conditions, not only glucose but also glucosamine and galactose can serve as potent stimulants for insulin release from the isolated, perfused rat pancreas. Since galactose and, probably, glucosamine are not metabolized in the islets, and since these three compounds have in all likelihood common sites of action, it is postulated that a glucoreceptor of broad specificity is inv...
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ژورنال
عنوان ژورنال: Metabolism
سال: 1967
ISSN: 0026-0495
DOI: 10.1016/0026-0495(67)90140-0